Cholesterol Lowering Agents: FIBRATES
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Fibric Acid Derivatives, or fibrates, are very effective at lowering triglyceride levels. Fibrates also lower LDL cholesterol, though generally to a lesser extent than the statins. They work by both decreasing cholesterol made in the liver and by increasing its removal through bile. Fibrates also mildly increase HDL cholesterol levels and studies have shown a reduction in cardiovascular complications when the use of fibrates was compared to placebo (a non-active medication or “sugar pill”).
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Side effects are usually mild.
Some patients may experience:
- Bloating
- Gas
- Heartburn
- Nausea
- Headache
- Dizziness
A rare but serious side effect is liver damage. Symptoms of liver damage include:
- Yellow skin or eyes
- Dark urine
- Nausea and vomiting
- Loss of appetite
Skeletal muscle problems have also been reported with this class of medications, particularly when they are used concurrently with statins. These problems occur very rarely.
If you have any problems that you feel are medication-related, please consult your healthcare provider.
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- Tell your provider if you are pregnant, breastfeeding or have liver disease.
- Avoid alcohol consumption.
- These medicines may make you dizzy.
- Avoid driving or using dangerous machinery.
- Tell your dentist that you are on this medication.
- This medication can cause harm to an unborn baby. Use an effective form of birth control and if you become pregnant while using this medication, tell your provider right away.
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