Cholesterol Lowering Agents: NIACIN
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Niacin, or nicotinic acid, is a water-soluble vitamin that in large doses has favorable effects on the lipid profile. Niacin reduces levels of LDL cholesterol and triglycerides. Its main effect, however, is increasing the level of HDL cholesterol. Niacin has also been shown to reduce cardiovascular disease. It has a very good safety profile, but also affects the liver and therefore requires close monitoring of liver function.
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Common side effects of niacin include:
- Flushing (redness or warmth of the face)
- Itching
- Stomach upset
- Mild dizziness
- Headache
These side effects often decrease over time as niacin therapy continues.
Niacin may worsen gout, diabetes, and stomach ulcers. A rare side effect of niacin is liver damage. This occurs more often with doses greater than 3000 mg daily or when using slow-release niacin products.
Symptoms of liver damage include:
- Yellow skin or eyes
- Dark urine
- Nausea and vomiting
- Loss of appetite
If you have any problems that you feel are medication-related, please consult your healthcare provider.
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Use of earlier forms of this medication was limited by flushing and itching. Newer formulations of this medication include slow-release forms that have been tolerated much better by patients. Some other ways to reduce the risk of flushing include taking Niacin with food and taking Aspirin about 30 minutes before the Niacin dose.
Tell your provider if you are pregnant, breastfeeding or have liver disease.
- Avoid alcohol consumption.
- These medicines may make you dizzy.
- Avoid driving or using dangerous machinery.
- Tell your dentist that you are on this medication.
- This medication can cause harm to an unborn baby. Use an effective form of birth control and if you become pregnant while using this medication, tell your provider right away.
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